Peptidylglycine alpha amidating enzyme
In addition to its rather complex functional profile, La also has a role in translation (27, 47).For example, La can bind to the internal ribosome entry sites (IRES) of hepatitis C virus (HCV) (3) and the X-linked inhibitor of apoptosis protein (22), in both cases stimulating translation initiation.In the case of the HCV IRES, which lacks a 3′ UUU, La binds specifically to an internal sequence near the initiator AUG codon (3, 36, 37). An N-terminal “La motif” is followed by either one or two RNA recognition motifs (RRMs; also referred to as RBDs or RNP domains) (46, 47).The elucidation of the mechanisms of regulation of PAM expression should bring new insights into the field of neuropeptide-processing enzyme regulation.
Recently, we demonstrated that thyroid hormones and estrogen affect PAM gene expression posttranscriptionally by altering m RNA stability (12, 15).
The size of La varies from about 32 k Da in yeasts, where La has only one RRM, to 50 k Da in humans, where La has two RRMs.
Peptidylglycine alpha amidating enzyme comments