Peptidylglycine alpha amidating enzyme


Tissue-specific alternative splicing of the primary transcript of a single-copy gene located on human chromosome 5 (32) generates numerous PAM m RNA transcripts (10, 33, 40).



In addition to its rather complex functional profile, La also has a role in translation (27, 47).For example, La can bind to the internal ribosome entry sites (IRES) of hepatitis C virus (HCV) (3) and the X-linked inhibitor of apoptosis protein (22), in both cases stimulating translation initiation.In the case of the HCV IRES, which lacks a 3′ UUU, La binds specifically to an internal sequence near the initiator AUG codon (3, 36, 37). An N-terminal “La motif” is followed by either one or two RNA recognition motifs (RRMs; also referred to as RBDs or RNP domains) (46, 47).The elucidation of the mechanisms of regulation of PAM expression should bring new insights into the field of neuropeptide-processing enzyme regulation.

Recently, we demonstrated that thyroid hormones and estrogen affect PAM gene expression posttranscriptionally by altering m RNA stability (12, 15).

The size of La varies from about 32 k Da in yeasts, where La has only one RRM, to 50 k Da in humans, where La has two RRMs.


Peptidylglycine alpha amidating enzyme comments


  • Mammalian Peptidylglycine α-Amidating Monooxygenase mRNA. profil de paulette60

    paulette60

    Peptidylglycine α-amidating monooxygenase PAM; EC 1.14.17.3 catalyzes the COOH-terminal α-amidation of peptidylglycine substrates, yielding amidated products. We have previously reported a putative regulatory RNA binding protein PAM mRNA-BP that binds specifically to the 3′ untranslated region UTR of.…
  • Genetic determinants of amidating enzyme activity and its. profil de paulette60

    paulette60

    Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum. Eric D Gaier,; Alison Kleppinger,; Martina Ralle,; Jonathan Covault,; Richard E Mains,; Anne M Kenny and; Betty A EipperEmail author. BMC Endocrine Disorders2014. https//doi.org/10.1186/1472-6823-14-58.…
  • Immunocytochemical localization of peptidylglycine alpha-amidating. profil de paulette60

    paulette60

    Original Article. 1. Immunocytochemical Localization of Peptidylglycine. Alpha-amidating Monooxygenase Enzymes PAM in Human Endocrine Pancreas'. ALFREDO MART~NEZ,~ LUIS M. MONTUENGA, DAVID R. SPRINGAU. ANTHONY TRESTON, FRANK CUTTITTA, and JULIA M. POLAK. Department of Cytology and.…